A Case of Therapy-resistant Chronic and Multiple Venous Leg Ulcers Treated Successfully with Trafermin Splay (Basic Fibroblast Growth Factor)

Abstract

We report a 88-years-old-man effective with Trafermin, who had chronic and multiple venous leg ulcers with long-standing resistance to therapy. He had three skin ulcers on his bilateral legs, 10.0 ×3.5 cm outside his rt. ankle joint, 4.5 × 2.3 cm ulcer inside his lt. ankle joint, and 14.0×10.0 cm ulcer outside his lt. ankle joint. We treated these ulcers by once-daily spraying of Trafermin. Two ulcers was completely epithelialized at 5～6 months after the beginning of the treatment and do not relapse till now. His biggest ulcer was also reduced the size to 8.5 × 5.0 cm at 10 months after the beginning of the treatment and good granulation with good epithelialization was observed. Trafermin was developed aiming at the basic fibroblast growth factor playing an important role in the wound healing process. The good effects of Trafermin was expected in the patients ineffctive with other drugs. Trafermin may be effective tretment for the shortening of treatment period with other surgical treatment.