A Case Report of Trousseau’s Syndrome in a Patient Treated with Edoxaban

Abstract

A 73-year-old woman visited our vein center complaining of right ankle pain. Duplex ultrasonography revealed superficial thrombophlebitis on the right ankle, with asymptomatic deep vein thrombosis in the right soleal veins. A computed tomography scan showed multiple thrombi in bilateral pulmonary arteries. She underwent anti-coagulation therapy with edoxaban as well as elastic compression stockings. Blood examination did not show any coagulation profile disorders (i.e., antithrombin deficiency, protein C deficiency, protein S deficiency, or antiphospholipid syndrome). Since the cause of venous thromboembolism (VTE) was unknown, we suspected her hypercoagulable state due to malignancy. After whole body examination, colonoscopy finally exhibited a colon carcinoma in the hepatic flexure. She underwent right colectomy with lymph node dissection under laparoscopic assistance. After 1-year follow-up, there were no recurrences either of malignancy or VTE.