Cytochalasin D as the Depressant of Contraction for the Optical Monitoring of Action Potentials in Isolated Rat Atrium

Abstract

We used cytochalasin D to reduce contraction-related optical signals by inhibiting muscle contraction for the optical monitoring of action potentials, using a voltage-sensitive dye in isolated rat atrium preparations. The suppression of contraction-related signals was so strong that we concluded that this chemical is suitable for this purpose.