Repeated Exposures to Hyperbaric Air Suppress Neurite Outgrowth in PC12 Cells

Tetsuro Isada; Munetaka Hirose; Eri Murata; Yoko Okayama; Mayumi Takatori; Mayumi Tani; Keita Fukazawa; Masashi Hirata; Satoshi Taniguchi; Kenji Shigemi; Yoshifumi Tanaka

doi:10.2170/physiolsci.SC009707

Short Communications

Repeated Exposures to Hyperbaric Air Suppress Neurite Outgrowth in PC12 Cells

Tetsuro Isada, Munetaka Hirose, Eri Murata, Yoko Okayama, Mayumi Takatori, Mayumi Tani, Keita Fukazawa, Masashi Hirata, Satoshi Taniguchi, Kenji Shigemi, Yoshifumi Tanaka

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Keywords: diving, hyperbaric air, nerve growth factor

JOURNAL FREE ACCESS

2007 Volume 57 Issue 5 Pages 321-325

DOI https://doi.org/10.2170/physiolsci.SC009707

View "Advance Publication" version (November 1, 2007).

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Abstract

Hyperbaric exposure induces lesions of the CNS in scuba divers. Repeated exposures to hyperbaric air at 0.5 MPa for 30 min with short intervals suppressed NGF-stimulated neurite outgrowth, concomitant with a decrease in the protein expression of ERK in PC12 cells. Hyperbaric exposure most likely causes direct lesions of neural cells.

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