Proceedings of the Japan Academy
Print ISSN : 0021-4280
Microbiological Degradation of Bile Acid
II. Formation of Δ4, 9(11)-7-Hydroxy-3, 12-diketobisnorcholadienic Acid from Cholic Acid by Actinomyces
Shohei HAYAKAWA
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1954 Volume 30 Issue 2 Pages 133-138

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Abstract
As described in a previous paper, the two new bile acids with m.p. 280-282° (decomp.) and 248° (decomp.) were obtained as the degradation products of cholic acid using Actinomyces No. 1164. The structure of the former, m.p. 280-282° (decomp.), is discussed and it is concluded that the acid possesses probably the structure of Δ4, 9(11)7-hydroxy-3, 12-diketobisnorcholadienic acid.
Acknowledgement: The author expresses his hearty thanks to Prof. T. Shimizu for his interest and his encouragement on this study, to Dr. K. Hirayama for his help in measuring the ultraviolet absorption spectra and for his valuable criticism, to Dr. H. Kimoto for his help in determining the polarographs, and also to Mr. T. Oshima and Miss K. Nakatsuka for their help in culturing.
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