The Third Way in Medical Investigation of Illness and the Clinical Significance of Adrenaline Sensitizer

Abstract

In the history of medicine the first scientific attempt to elucidate the cause of illness and to find a treatment for it was the effort to establish a disease entity through symptomatology and to discover a specific agent as a cause of specific disease entity.
After this method a new way was suggested by Selye. He emphasized the common basic reaction pattern of the living organism against injuries regardless of their origins. And he clarified that the exploration of these basic reaction patterns induced by stress is the second way in medical investigation to elucidate the cause of the unknown pathological condition and to find a new treatment.
The author pointed out a third way, i.e. the search for a new substance, which changes the sensitivity of the living organism to hormones or to a potent biological substance mobilized by stress as a stress factor, might be a promising new way in the medical investigation of illness.
In this way the author discovered the “adrenaline sensitizer” from the gram-negative bacilli, especially abundantly in the bacilli causing “Ekiri”. a malignant syndrome due to shigellosis and some salmonellosis. Also the adrenaline sensitizer was found in the blood of Ekiri patients and it was clarified that the combined effect of adrenaline, especially noradrenaline, induced by the stress of infection, and the adrenaline sensitizer liberated from the causative bacilli may cause the malignant syndrome. It was also shown that the adrenaline sensitizer may have an important significance as a cause not only of the malignant syndrome in infections but also of the other pathological phenomena of the human.
According to the third way, not only the adrenaline sensitizer, but also sensitizer or desensitizer of the other hormones will be found from causative parasitic microorganisms of unknown pathological condition or from the blood or tissue of patients suffering unclarified pathological conditions in the future and they might bring a new progress to medicine.