Biliary Amylase Output in Rats with Pancreatic Duct Obstruction and CCl₄-Intoxication

Abstract

Effects of hyperamylasemia in vivo on biliary amylase output were examined with special attention to the interrelation among bile flow, plasma amylase level and biliary amylase. Experimental hyperamylasemia was produced by pancreatic duct obstruction and by CCl₄-intoxication. Amylase level in the bile was elevated with a positive correlation to palsma amylase level in rats with pancreatic duct obstruction or chronic CCl₄-intoxication. Biliary amylase output was increased with a positive correlation to amylase level in the bile in untreated rats and in rats with pancreatic duct obstruction. However, in rats with chronic CCl₄-intoxication, no significant increase in biliary amylase output was found, although amylase level was significantly elevated both in the bile and in the blood plasma. Amylase level in the bile was elevated by chronic CCl₄-intoxication, and it had a positive correlation with plasma levels of transaminase. A significant decrease in urinary excretion of amylase was also observed in rats with chronic CCl₄-intoxication.