Inhibitory Action of Adenosine and Adenine Nucleotides on the Postsynapptic Potential of Olfactory Cortex Slices of the Guinea Pig

Abstract

Adenosine and adenine nucleotides (5×10^-6-10^-3M) had inhibitory action on the N-wave (a post-synaptic potential) amplitude of olfactory cortex slices of guinea pig where-as they showed no depressant effect on the PSP of superior colliculus slice. On the contrary 5-HT (10^-5M) and GABA (10^-4-10^-3M) had no inhibitory action on the N-wave of olfactory cortex slice although they depressed markedly the PSP of the slices of superior colliculus.