Pseudohyphal growth induced by exposure of yeast cells to subinhibitory levels of antifungal azoles in Candida tropicalis.

Takahito Suzuki; Shin-Ichi Iwaguchi; Teijiro Kamihara

doi:10.5685/plmorphol.13.2

Takahito Suzuki, Shin-Ichi Iwaguchi, Teijiro Kamihara

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Keywords: antifungal agents, Candida tropicalis, pseudohyhal growth

JOURNAL FREE ACCESS

2001 Volume 13 Issue 1 Pages 2-10

DOI https://doi.org/10.5685/plmorphol.13.2

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Published: 2001 Received: December 28, 2001 Available on J-STAGE: June 28, 2010 Accepted: - Advance online publication: - Revised: -
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Date of correction: June 28, 2010 Reason for correction: - Correction: PDF FILE Details: -

Date of correction: June 28, 2010 Reason for correction: - Correction: KEYWORD Details: Wrong : Key Words: antifungal agents, Candida tropicalis, pseudohyhal growth
Right : antifungal agents, Candida tropicalis, pseudohyhal growth

Date of correction: June 28, 2010 Reason for correction: - Correction: CITATION Details: Wrong : E
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Abstract

Summary: The azole class of compounds kills fungal cells through an inhibition of ergosterol biosynthesis resulting in malfunction and breakdown of cell membranes. Subinhibitory levels of these compounds were found bringing about a transition from yeast form to pseudohyphal one in Candida tropicalis, as well as ethanol reported previously. The other classes of inhibitors for ergosterol biosynthesis, terbinafine and amorolfin, also caused the transition. These findings implicated the function of ergosterol for filamentous growth. Although depolarized cell growth was observed to precede filamentation during the process of ethanol-induced pseudohyphal formation in this organism, no distinct depolarization was found to occur during the process induced by these antifungal compounds.

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