2023 Volume 12 Pages 1-7
Immune system aging (immune senescence) is an important factor contributing to the increased incidence and mortality rates among the elderly. Immune senescence, characterized by a decline in immune function, can also lead to aging and tissue dysfunction in organs as well as the lymphatic system. This suggests that aged immune cells may contribute to systemic aging. Conversely, transplantation of young immune cells into aged mice has been shown to improve systemic aging traits, indicating that immune system senescent cells could be a significant therapeutic target for promoting healthy aging. However, the molecular mechanisms behind immune senescence are not fully understood. Advances in unraveling these molecular processes are expected to lead to the discovery of new methods for preventing aging and extending lifespan.
