Cytokine　of NH　lymphadenitis

Abstract

　　　A　surplus　of　cytokine　production　and　an　overreaction　ofhistiocytes　and　macrophages　that　lead　to　necrosis are　considered　to　be　possibly　associated　with　subacute　necrotizing　lymphadenitis（Kikuchi－Fujimoto　disease）， but　descriptions　in　the　pediatric　literature　are　sparse．　To　better　understand　this　disease　in　children　we　investigated their　cytokine　profiling　and　immunohistochemical　staining．　The　serum　levels　of　IL-6，　IFN-γ，　MIP-13　and　TNF-α were　significantly　high　compared　with　those　of　the　controls．　On　immunohistochemical　staining，　cytotoxic　T cells　mainly　infiltrated　the　necrotic　area．　Extremely　high　levels　of　IFN-γ suggest　that　chronic　viral　infection　had occurred，　and　chemokines　might　have　increased　due　to　inflammation　after　infection．　There　was　no　significant difference　in　serum　cytokines　between　in　SLE　and　subacute　necrotizing　lymphadenitis．　From　these　findings　long-term -follow　up　is　recommended．