2010 Volume 3 Issue 2 Pages 85-88
ubulointerstitial nephritis and uveitis（TINU）syndrome which complicates tubulointerstitial nephritis and uveitis was first described in 1975． Since then，200 or more cases with TINU syndrome have been reported in Japan． We report a case with TINU syndrome． Patient was a l5-year01d girl，who had complained of photophobia and conjunctival injection． Ophthalmologist made her a diagnosis of uveitis，and some renal diseases．We performed renal biopsy．An accumulation of inflammatory cells such as neutrophils and monocytes，and renal tubular atrophy were revealed．We diagnosed her as TINU syndrome because of the combination of serious tubulointerstitial nephritis and uveitis． Her photophobia and conjunctival injection had improved by conjunctival instillation of corticosteroid． However，the nephritis was so serious that we chose methylprednisolone pulse therapy of two courses， and after the courses，oral prednisolone 30mg/day was started and gradually tapered．After six months from the onset，the second renal biopsy was perfbrmed．In results，her interstitial nephritis was improved． In the present case， her complaints came only from uveitis but not from interstitial nephritis． Nevertheless，her nephritis was serious、It is suggested that，even in cases with few renal symptoms、the level of nephritis varies，so that we have to select therapy carefully．Steroids are commonly effective for TINU syndrome． But uveitis and interstitial nephritis may occasionally worsen in the clinically course． We have to pay attention to follow-up even after the improvement．
