Abstract
ubulointerstitial nephritis and uveitis（TINU）syndrome which complicates tubulointerstitial
nephritis and uveitis was first described in 1975． Since then，200 or more cases with TINU syndrome have
been reported in Japan． We report a case with TINU syndrome． Patient was a l5-year01d girl，who had
complained of photophobia and conjunctival injection． Ophthalmologist made her a diagnosis of uveitis，and
some renal diseases．We performed renal biopsy．An accumulation of inflammatory cells such as neutrophils
and monocytes，and renal tubular atrophy were revealed．We diagnosed her as TINU syndrome because of the
combination of serious tubulointerstitial nephritis and uveitis． Her photophobia and conjunctival injection had
improved by conjunctival instillation of corticosteroid． However，the nephritis was so serious that we chose
methylprednisolone pulse therapy of two courses， and after the courses，oral prednisolone 30mg/day was started
and gradually tapered．After six months from the onset，the second renal biopsy was perfbrmed．In results，her
interstitial nephritis was improved．
In the present case， her complaints came only from uveitis but not from interstitial nephritis．
Nevertheless，her nephritis was serious、It is suggested that，even in cases with few renal symptoms、the level of
nephritis varies，so that we have to select therapy carefully．Steroids are commonly effective for TINU syndrome．
But uveitis and interstitial nephritis may occasionally worsen in the clinically course． We have to pay attention to
follow-up even after the improvement．
