Abstract
Influence of Sr2+ on the formation and structure of calcium hydroxyapatite (Ca10(PO4)6(OH)2: CaHap) particles prepared by hydrolyzing the phenyl phosphate (C6H5PO4H2) using alkaline phosphatase (ALP) at 37°C was examined. Increasing the additional amount of Sr2+ increased the Sr content in the products and turned the crystal phase of the products as follow: CaHap → solid solution SrCaHap → Sr1.7Ca1.3(PO4)2 → (3Sr(HPO4)2·Sr3(PO4)2)·2H2O. All the phenyl phosphates were hydrolyzed by ALP at 37°C. The crystallinity and particle size of CaHap decreased with an increase of added Sr2+, meaning the inhibition of crystallization and particle growth. These facts suppose that incorporation of Sr2+ in animal organism suppresses the formation of hard tissues.
