PHOSPHONYLATION OF CATECHIN WITH SODIUM DIPHOSPHONATE IN AQUEOUS SOLUTION

Hideko Maeda; Yoko Terashita; Tadashi Matsushima; Takeshi Nagai; Mitsutomo Tsuhako; Hiroyuki Nariai; Hirokazu Nakayama

doi:10.3363/prb.27.6

Hideko Maeda, Yoko Terashita, Tadashi Matsushima, Takeshi Nagai, Mitsutomo Tsuhako, Hiroyuki Nariai, Hirokazu Nakayama

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Keywords: Phosphonylation, Catechin, Diphosphonate, HPLC, 31P NMR

JOURNAL FREE ACCESS

2012 Volume 27 Pages 6-10

DOI https://doi.org/10.3363/prb.27.6

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Abstract

Phosphonylation of catechin (CA) has been achieved using inorganic diphosphonate (DP) in aqueous solution. The optimum condition for the phosphonylation of catechin with DP is CA : DP = 1 : 10, pH 6 and 25 °C. 3'-Phosphonylcatechin and 4'-phosphonylcatechin were synthesized with the total yield of more than 25 %. The phosphonylated products of CA were stable at 10 °C and pH 3. The reaction mechanism of CA with DP was discussed.

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