THE EFFECTS OF SBF CONDITIONS ON ENCAPSULATION OF AGAROSE GEL WITH HYDROXYAPATITE MICROCAPSULES

Abstract

By raising the temperature or the pH of an acellular simulated body fluid (SBF), nanoparticles of amorphous calcium phosphate are precipitated. The nanoparticles are highly active to induce hydroxyapatite formation in body fluid or SBF. In this study, the authors fabricated hydroxyapatite microcapsules encapsulating an agarose gel by using the nanoparticles and examined the effects of the pH and the concentrations of SBF on the microcapsules formation process. Increase in ion concentrations or raising pH of SBF caused the acceleration of the microcapsules formation.