Abstract
Biocompatible nanoparticles have been widely studied as carriers for drug delivery systems. In our previous work, Poly(Lactic acid) / hydroxyapatite core-shell nanoparticles prepared by a surfactant-free emulsification method indicated a drug loading capacity value of 250 % for water-insoluble substances. In addition, the nanoparticles showed pH sensitivity to release the drug. In the process of preparing the core-shell nanoparticles, acetone was used as a solvent to dissolve PLA and hydrophobic substances. However, some substances have poor solubility to acetone. In this work, the core-shell particles were prepared using different solvents, such as tetrahydrofuran (THF) and trifluoroethanol (TFE), to further improve their substance-loading properties. The core-shell nanoparticles prepared using THF and TFE showed a similar morphology to that of acetone. Furthermore, their structure showed no significant difference between the solvents used for preparation. Therefore, changing the solvent to prepare core-shell nanoparticles may not result in any change in the properties of the particles. Accordingly, the core-shell nanoparticles prepared with THF and TFE have the potential to improve drug loading ability for various substances.
https://ror.org/01703db54 
