Abstract
Porous hydroxyapatite (HAp) films were formed on α-Al2O3 substrate by spray-pyrolysis technique, using starting solutions with the Ca/P ratios of 0.50 and 3.00. The crystalline phase of the resulting films was mainly HAp; the films were porous and the thickness was ~30 μm. Even after Scotch tape (#810) was adhered to the films and then taken off from the substrates, the films were still present on the substrate. The biocompatibility of the α-Al2O3 coated with HAp was examined using osteoblastic cells (MC3T3-E1). The cells on the α-Al2O3 coated with HAp were proliferated in a similar manner to the case of control (dish for cell culture) and the α-Al2O3 substrate without HAp coating; the alkaline phosphatase (ALP) activity of the cells cultured on the α-Al2O3 coated with HAp for 21 days showed the highest value among the examined specimens.
