FORMATION OF INTERMOLECULAR COMPLEX AND POLYMER-DRUG INTERACTION ON THE SURFACE OF HYDROXYAPATITE IN AN AQUEOUS PHASE

Abstract

Triton X-100, water-soluble but non-adsorbable to HAP, was adsorbed after formation of a mixed hemimicelle together with SDS. Water-insoluble dye, MY, was incorporated into an SDS aggregate formed on the surface in a similar manner to that of ordinary solubilization performed in an aqueous phase. Water-soluble polymer HPC formed a surface complex of SDS-HPC, which bridged among HAP particles, resulting in flocculation of the particles. Water-soluble MO was captured by BSA adsorbed on HAP, resulting in an increase in its amount of adsorption on the surface of HAP. Mono- and dialkylphosphate was adsorbed to HAP in a similar manner to that of SDS, i.e., after isomorphous substitution. Understanding these phenomena is important for understanding mechanisms of the interaction between drugs and hard tissues and the absorption of drugs into hard tissues as well as the formation of animal hard tissues composed of HAP and organic compounds.