Abstract
To investigate neural mechanisms underlying behavioral set-shift, we trained animals to perform an oculomotor set-shift task which required search for a correct pair of saccade targets by trial and error. In this task, a trial began when the animal fixated on a center spot and, after a delay period, four spots were illuminated. Then after another delay period, the center spot was extinguished and served as a GO signal. The animal was required to make saccade to one of four spots. A correct target was shifted between a pair of spots in every trial. The target pair was shifted in block without any instruction. Thus animals were required to search a new correct pair by trial and error. We recorded from the supplementary eye field (SEF), while the animal performed this task. Here we report some task-related neuronal activity that characterizes the SEF. [Jpn J Physiol 54 Suppl:S181 (2004)]
