Abstract
[Background] Prolongation of intestinal paralytic state after abdominal operation is a severe problem in the field of surgery. It may cause bacterial flora disorder which lead to bacterial translocation and may trigger complications. In order to prevent this, early recovery from this state is required. [Aim] The aim of this study is to evaluate the effects of epidurally infused Morphine to the recovery of postoperative ileus. [Subjects and Methods] 10 mature hound dogs (10-12kg)were separated to 2 groups. Catheters were inserted into the epidural space. Under general anesthesia laparotomy was done. Strain gauge force transducers (SGT) were sutured to the surface serosa of the body and antrum of stomach, duodenum, jejunum and ileum. Drug infusion started at the time of operation.(a)Natural saline (n=5), b)Morphine sulfate 0.08mg/ml in saline (n=5)).Motility recording started immediately after the operation. [Results] The appearance of first phase 3 was as below. (Hrs after operation(SD)): Body,antrum,duodenum,jejunum,ileum. SALINE:115.0(23.6),72.8(14.1),59.0(16.1),45.7(4.2),34.3(5.8).MORPHINE:50.7(11.3),49.0(11.4),20.8(9.7),12.8(7.7),2.7(1.6).The contractile force of the first phase 3 did not show significant difference between the two groups. [Conclusion] Morphine is often considered to disturb gut motility. In this study morphine suppressed intestinal motility after laparotomy with enough contractile power. We suspect that epidural use of morphine after abdominal surgery is a successful method for early recovery. [Jpn J Physiol 54 Suppl:S186 (2004)]
