Abstract
We devised an apparatus (CMP) to keep watch behavior from food-acquisition to feeding termination in mice. The system compelled them to climb a cylindrical wire net of 180 cm high in order to acquire food. CMP characterized feeding behavior when being fed and starved. Such characters were assumed to be derived from changes in blood glucose levels. Thus effects of supplying glucose were examined on the feeding behavior.C57 BL/6J mice were introduced into CMP at 8 wk old. Acclimating 28-35 days, behavior was measured for 2 hr from beginning dark period under fed and starved conditions. Administered were glucose (2 g/kg bw, i.p., GL), 2-deoxy-D-glucose (500 mg/kg bw, i.p., 2-DG) or same volume of saline. GL decreased food consumption while 2-DG increased it. GL gave no changes in food-acquiring behavior under both fed and starved conditions. 2-DG suppressed the behavior under only the starved condition. Thus blood glucose and 2-DG might affect feeding behavior. But the effects were different between food consumption and food-acquiring behavior. [Jpn J Physiol 54 Suppl:S207 (2004)]
