Abstract
Recently, there is an explosive increase in the expectation that the transplanted bone marrow stromal cells (BMSC) may regenerate the damaged central nervous system (CNS) and improve neurological function. Indeed, numerous reports have shown that the transplanted BMSC migrate into the damaged CNS and differentiate into the neural cells, improving neurological deficits in various animal models. However, there still is a considerable gap between their histological findings and neurological behaviors. The authors have run the following experiments for these 3 years in order to explore how the transplanted BMSC improve their neurological findings: (1) Establishment of BMSC transplantation system for mice cerebral infarct or spinal cord injury model, (2) Establishment of autogeneic BMSC transplantation into the rat brain and spinal cord, and (3) Fluorescence bioimaging of the BMSC transplanted into mice cerebral infarct or rat spinal cord injury model.In this symposium, the authors will present the additional results obtained from other ongoing experiments. [Jpn J Physiol 54 Suppl:S22 (2004)]
