Abstract
The symptoms of hypertension and/or hypercholesterolemia were improved by continuous exercise. In these diseases, the activity of the reactive oxygen species, that is oxidative stress, rises remarkably. In this reserch, the changes of superoxide generation via heart, kidney, liver and aorta abdominals were measured and the controlling effect of continuous exercise was evaluated. Dhal salt-sensitive rat (16 weeks) inducted hypertension and/or hypercholesterolemia with continuous exercise, that was swimming, were used. Samples were obtained from delivered organs by punch biopsy and superoxide generation was measured by chemiluminescense of Lucigenin. As results, superoxide generation via heart of hypertension rat was controlled to the same level of control rats. It was suggested that the rise of superoxide generation promoted by hypertension was inhibited by continuous exercise. [Jpn J Physiol 55 Suppl:S105 (2005)]
