Abstract
We have previously shown that intravenous infusion of 2-deoxy-D-glucose (2DG) induced the differential responses in sympathetic outflows; renal sympathetic nerve activity (RSNA) and lumbar sympathetic nerve activity (LSNA) decreased immediately after the administration of 2DG , then RSNA returned to the control level while LSNA remained the low level in intact rats. The present study aimed to investigate a potential role of sino-aortic baroreceptors in the regional difference in sympathetic nerve activity induced by the 2DG administration. Wistar male rats were sino-aortic denervated (SAD) and instrumented chronically with electrodes for the measurements of RSNA and LSNA and catheters for the measurements of systemic arterial and central venous pressures. At least two days after the surgery, a bolus infusion of 750 mg/kg of 2DG was performed following 1 h of control period. Both RSNA and LSNA suppressed immediately after the administration of 2DG in SAD rats, which was consistent with those in the intact rats. RSNA returned to the control revel, which was also consistent with the observation in the intact rats. However, LSNA returned to the control level in SAD rats, while LSNA remained the low level in the intact rats. These results suggest the sustained suppression of LSNA following the 2DG administration in the intact rats may be induced by inhibitory influence of the sino-aortic baroreceptors. It is therefore possible that sino-aortic baroreceptors may influence sympathetic nerve activity in regionally different manner. [Jpn J Physiol 55 Suppl:S192 (2005)]
