Abstract
Cilostazol, an antiplatelet agent, increases cerebral blood flow and can be expected to improve brain function. We investigated effect of Cilostazol on learning disability by transient cerebral ischemia in the mouse. Subjects (14 male C57BL/6 mice) were trained for reacting to illuminated key as soon as possible using operant conditioning technique. After the reaction time became stable, the mice were subjected bilateral common carotid artery occlusion for 10 min followed by reperfusion. From the next day of the operation, a half of the subjects was administrated orally 50 mg/kg Cilostazol with Methyl Cellulose solution and the other half was exposed to the Methyl Cellulose solution as a control group. From a week after the operation, subjects were re-trained and the reaction time and the correct response ratio were compared between these two groups. In the control group, the correct response ratio was decreased sharply at soon after the operation and then recovered quickly. From around 50 days after the operation, temporal decrease of the correct reaction was observed. In the Cilostazol group, although the fall of the correct reaction ratio was steeper than that in the control group, there was no temporal decrease in the chronic phase observed in the control. In the both groups, the reaction time and the correct reaction ratio were not recovered to those of pre-operation level by re-training for three months. From these results we suggested that Cilostazol may diminish the learning disability in the chronic phase. [Jpn J Physiol 55 Suppl:S201 (2005)]
