Abstract
Exposure of humans to space flight condition resulted in numerous alterations in immunological and hormonal parameters. Similar changes are observed during head-down bed rest (HDBR). The mechanism and responsible factors of the changes in immunological parameters induced by space flight are not clear. The aim of this study was to investigate whether exposure to the "stress" environment are responsible for alterations in synthesis of this parameters and if the changes occur, there are possibility to use exercise to prevent this negative effect. In the study 12 volunteers were subjected for 20 days to a HDBR of -6 degree; 6 of them were exposure to physical exercise. The following parameters have been analyzed: noradrenaline (NA), adrenaline (Adr), dopamine, ADH, angiotensin II, aldosteron, ANP and BNP, renin plasma activity (PRA), peripheral white blood cells count (WBC), IL- 6, total serum protein (TP), CRP and α-1antichimotrypsin (ACT). In all subjects after HDBR: Adr, NA and PRA concentrations increased significantly, CRP decreased (ANOVA p<0.05).Concentrations of TP, ACT, CRP and WBC tended to be increase after 3 day of HDBR. Concentration of TP in non-exercise group was higher than in exercise group after 20 day of HDBR. We didnt observe differences between concentrations of other analyzed parameters in subjects maintained in these two groups. The results of this study indicate that several parameters are modulated by an antigravity posture during HDBR. [J Physiol Sci. 2007;57 Suppl:S87]
