Abstract
alpha-klotho was first identified as the gene responsible for premature ageing-like phenotypes in a short-lived mouse model. We found the molecular association of alpha-Klotho and Na+,K+-ATPase and subsequently a novel alpha-Klotho dependent pathway that recruits Na+,K+-ATPase to the plasma membrane. Low [Ca2+]e rapidly induces regulated PTH secretion, in an alpha-Klotho and Na+,K+-ATPase dependent manner. The increased Na+ gradient created by Na+,K+-ATPase activity might drive the transepithelial transport of Ca2+ in cooperation with ion channels and transporters in the choroid plexus and the kidney. Our findings provide a paradigm for the fundamental roles of alpha-Klotho in the regulation of calcium metabolism. [J Physiol Sci. 2007;57 Suppl:S88]
