Abstract
Acute liver disease was induced in mice by carbon tetrachloride treatment. Levels of serum albumin, F-SH, T-SH, B-SH and total protein in the blood were then measured at 24 h after carbon tetrachloride intoxication.In comparison to controls, the liver injury group showed significantly greater increases in serum albumin (1.11-fold increase relative to controls, p<0.01), F-SH (1.48, p<0.005), B-SH (1.64, p<0.001) and T-SH (1.59, p<0.001).A correlation was observed between increases in B-SH and F-SH, thus suggesting that B-SH increases as a result of increased F-SH, with reactivity and subsequent binding of the products of liver injury. These findings suggest that F-SH acts as a buffer for substances, such as unnecessary or waste products in the body, and that a complex mechanism is involved in the production of SH groups. [J Physiol Sci. 2007;57 Suppl:S116]
