Abstract
= Purpose = The physiological properties of monosaccharides have not been studied well because most of them are rare in the nature. Angiogenesis, formation of new capillary blood vessels, plays an important role in a variety of normal and abnormal physiological processes, such as in embryonic development, tumor growth and metastasis. In 2005, we reported the effects of 36 monosaccharides on the proliferation and the tube formation of human umbilical vein endothelial cells(HUVEC). Some of them inhibited the proliferation and/or the tube formation, and these active sugars possessed some common structures. In this work, we added the data of other 7 monosaccharides. Together with the previous data, further structure activity relationship will be discussed. = Conclusion = We previously reported that the absence of OH group at the equatorial position of C2 or C3 is essential to cause inhibition. This means the increase in the hydrophobicity or the decrease in the steric hindrance around the area. Present data also supported this structure activity relationship, and revealed that the former reason is responsible for the inhibition. [J Physiol Sci. 2007;57 Suppl:S123]
