Microinjection of urocortin into the rat nucleus tractus solitarii decreases arterial blood pressure

Toshiya Yamazaki; He Cui; Ken Nakamura; Ken Kouda; Atsutoshi Hatada; Yuji Tsubota; Kazunori Yukawa; Masanobu Maeda

doi:10.14849/psjproc.2007.0_211_3

Proceedings of Annual Meeting of the Physiological Society of Japan

Session ID : 3PIA-015

DOI https://doi.org/10.14849/psjproc.2007.0_211_3

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Microinjection of urocortin into the rat nucleus tractus solitarii decreases arterial blood pressure

*Toshiya Yamazaki, He Cui, Ken Nakamura, Ken Kouda, Atsutoshi Hatada, Yuji Tsubota, Kazunori Yukawa, Masanobu Maeda

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Keywords: urocortin, nucleus tractus solitarii(NTS), cardiovascular effects, central control mechanisms of circulation, medulla oblongata

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Abstract

Urocortin (Ucn), a member of the corticotrophin-releasing factor (CRF) peptide family, has appetite-suppressing and cardiovascular effects. Its intravenous or subcutaneous injection of Ucn reportedly decreased the mean arterial blood pressure (MABP) and increased the heart rate (HR). We report that at 50 and 75 pmol/50 nl, Ucn, suspended in artificial cerebrospinal fluid (ACSF) and microinjected into the rat nucleus tractus solitarii (NTS), produced a significant, dose-dependent reduction in both MABP and HR. Our results suggest that Ucn may act as a neurotransmitter or neuromodulative substance in the NTS and that it may play a role in cardiovascular regulation in vivo. [J Physiol Sci. 2007;57 Suppl:S211]

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