Abstract
This report deals with effects of intravenous or intra-portal injection of glycerol, a metabolic product of adipose tissue, on efferent activity of sympathetic nerve innervating white adipose tissue(WAT) of epididymis and afferent activity of hepatic branch of vagus nerve in anesthetized rats. 1) Intravenous injection (100ng-10microg) or intra-portal injection (10ng) of glycerol suppressed sympathetic nerve activity to WAT. 2) After sectioning of hepatic vagus nerve or right vagus trunk, iv injection of glycerol was showed no effect. 3) Intra-portal injection of glycerol (10ng) suppressed afferent nerve activity of hepatic branch of vagus nerve.Results of experiments suggest that hepato-portal glycerol sensors play a role as an input of negative feed-back circuit which suppress efferent activity of sympathetic nerve innervating WAT which in turn may suppress lipolysis. [J Physiol Sci. 2008;58 Suppl:S50]
