Effect of countermeasure on body fluid shift and myatrophy induced by head-down bed rest in human healthy volunteers

Hiroki Sakurai; Satoshi Iwase; Junichi Sugenoya; Yoshihisa Masuo; Naoki Nishimura; Yosuke Yamada; Megumi Ohta; Shinji Tomita; Tetsuo Fukunaga; Koji Ishida; Hiroshi Akima; Keisyou Katayama; Yuuki Shimizu; Maki Sato; Kanikowska Dominika; Satomi Suzuki; Yoriko Watanabe; Kaname Hirayanagi; Tomoki Shiozawa

doi:10.14849/psjproc.2008.0_108_2

Proceedings of Annual Meeting of the Physiological Society of Japan

Session ID : 1P-I-189

DOI https://doi.org/10.14849/psjproc.2008.0_108_2

Conference information

Host: The Physiological Society of Japan

Effect of countermeasure on body fluid shift and myatrophy induced by head-down bed rest in human healthy volunteers

*Hiroki Sakurai, Satoshi Iwase, Junichi Sugenoya, Yoshihisa Masuo, Naoki Nishimura, Yosuke Yamada, Megumi Ohta, Shinji Tomita, Tetsuo Fukunaga, Koji Ishida, Hiroshi Akima, Keisyou Katayama, Yuuki Shimizu, Maki Sato, Kanikowska Dominika, Satomi Suzuki, Yoriko Watanabe, Kaname Hirayanagi, Tomoki Shiozawa

Author information

*Hiroki Sakurai
Dept.Physiol.,Sch.Med.,Aichi Med.Univ.,Aichi,Japan
Dept.Algesiol.,Sch.Med.,Aichi Med.Univ.,Aichi,Japan
Satoshi Iwase
Dept.Physiol.,Sch.Med.,Aichi Med.Univ.,Aichi,Japan
Junichi Sugenoya
Dept.Physiol.,Sch.Med.,Aichi Med.Univ.,Aichi,Japan
Yoshihisa Masuo
Sch Human Sci Waseda Univ, Tokorozawa, Japan
Naoki Nishimura
Dept.Physiol.,Sch.Med.,Aichi Med.Univ.,Aichi,Japan
Yosuke Yamada
Kyoto Univ, Kyoto, Japan
Megumi Ohta
Sch Human Sci Waseda Univ, Tokorozawa, Japan
Shinji Tomita
Sch Human Sci Waseda Univ, Tokorozawa, Japan
Tetsuo Fukunaga
Sch Human Sci Waseda Univ, Tokorozawa, Japan
Koji Ishida
Institute Phys Fitness and sports, Nagoya Univ, Nagoya, Japan
Hiroshi Akima
Institute Phys Fitness and sports, Nagoya Univ, Nagoya, Japan
Keisyou Katayama
Institute Phys Fitness and sports, Nagoya Univ, Nagoya, Japan
Yuuki Shimizu
Dept.Physiol.,Sch.Med.,Aichi Med.Univ.,Aichi,Japan
Maki Sato
Dept.Physiol.,Sch.Med.,Aichi Med.Univ.,Aichi,Japan
Kanikowska Dominika
Dept.Physiol.,Sch.Med.,Aichi Med.Univ.,Aichi,Japan
Satomi Suzuki
Sch Nurs Aichi Med Univ, Nagakute, Japan
Yoriko Watanabe
Sch Nurs Seirei Christopher Univ, Hamamatsu, Japan
Kaname Hirayanagi
Dept Hygiene Nihon Univ Sch Med, Tokyo, Japan
Tomoki Shiozawa
Aoyama Gakuin Univ, Tokyo, Japan

Keywords: microgravity, segmental bioimpedance method, body fluid shift, myatrophy, head-down bed rest

CONFERENCE PROCEEDINGS FREE ACCESS

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Abstract

Exposure of humans to microgravity condition resulted in body fluid shift and myatrophy. The aim of this study was to test the effectiveness of artificial gravity and ergometric exercise as countermeasure to these changes. 12 healthy young men were exposed to stimulated microgravity for 20 days by head-down bed rest. 6 subjects randomly selected were subjected to 1.4G of artificial gravity with 60W of ergometric workload everyday for 30 minutes (CM group). The rest of the subjects served as the control (control group). In head-up tilt test and Anti-G test, body fluid shift measured by segmental bioimpedance method was smaller in the trunk in CM group than in control group. Also, myatrophy measured by MRI in the thigh was smaller in CM group than in control group. Artificial gravity with exercise appeared to be effective in preventing changes in body fluid shift and myatrophy due to microgravity exposure. [J Physiol Sci. 2008;58 Suppl:S108]

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