Proceedings of Annual Meeting of the Physiological Society of Japan
Proceedings of Annual Meeting of the Physiological Society of Japan
Session ID : 1P-I-199
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Effects on brain tissue-oxygen level during acceleration stress in anesthetized rats
*Satoshi MaruyamaTomoko ManabeKazuo KatoYoshiaki SatoMegumi Tandai-HirumaTakehito KemuriyamaHiroyuki OhtaYasuhiro Nishida
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Abstract
High sustained +Gz stress has been known to provoke G induced loss of consciousness and central nervous system insults. Direct recording of tissue PO2 in the brain during +Gz exposure has not yet been reported. The purpose of this study is to evaluate effects of +Gz stress in the brain PO2. Anesthetized male SD rats were exposed to +3Gz by a centrifuge with an anti-G suit. Arterial pressure level of the brainstem (APLB), central venous pressure, heart rate and PO2 of the brain were measured. Cortical and hippocampal PO2 were simultaneously measured by a PO2 monitor with the polarographic oxygen electrodes. A decrease in APLB was observed twice: during the phase of increasing +Gz and the phase of decreasing +Gz. At these lowest points, cortical and hippocampal PO2 were also decreased significantly (first: 83.0 ± 2.4% and 68.8±4.4%; second: 81.0 ± 1.6% and 71.7 ± 6.7%; vs. control). APLB was restored to the control level just after the +Gz exposure was stopped. However, cortical PO2 was not restored to the control level over 5 minutes after the +Gz stop, although hippocampal PO2 was restored until 1 minute. +Gz induced hypotension involved a decrease in brain-tissue oxygen concentration. However, the time course of the PO2 changes during the +Gz exposure were different between cortex and hippocampus. This result may describe that the +Gz effect on the brain oxygen concentration is different dependently on the brain areas. [J Physiol Sci. 2008;58 Suppl:S110]
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© 2008 The Physiological Society of Japan
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