Electrophysiological-neurochemical-behavioral studies of integrative mechanisms of the macaque orbitofrontal cortex using visual category discrimination task

Balazs Lukats; Takao Inoue; Masaharu Mizuno; Laszlo Lenard; Yutaka Oomura; Zoltan Karadi; Shuji Aou

doi:10.14849/psjproc.2008.0_147_2

Proceedings of Annual Meeting of the Physiological Society of Japan

Session ID : 2P-G-122

DOI https://doi.org/10.14849/psjproc.2008.0_147_2

Conference information

Host: The Physiological Society of Japan

Electrophysiological-neurochemical-behavioral studies of integrative mechanisms of the macaque orbitofrontal cortex using visual category discrimination task

*Balazs Lukats, Takao Inoue, Masaharu Mizuno, Laszlo Lenard, Yutaka Oomura, Zoltan Karadi, Shuji Aou

Author information

*Balazs Lukats
Department of Brain Science and Engineering, Kyushu Institute of Technology
Institute of Physiology and Neurophysiology Research Group of the Hungarian Academy of Sciences, Pecs University, Medical School, Pecs, Hungary
Takao Inoue
Department of Brain Science and Engineering, Kyushu Institute of Technology
Masaharu Mizuno
Department of Brain Science and Engineering, Kyushu Institute of Technology
Laszlo Lenard
Institute of Physiology and Neurophysiology Research Group of the Hungarian Academy of Sciences, Pecs University, Medical School, Pecs, Hungary
Yutaka Oomura
Department of Integrative Physiology, Kyushu University, Faculty of Medicine, Fukuoka, Japan
Zoltan Karadi
Institute of Physiology and Neurophysiology Research Group of the Hungarian Academy of Sciences, Pecs University, Medical School, Pecs, Hungary
Shuji Aou
Department of Brain Science and Engineering, Kyushu Institute of Technology

Keywords: Macaca mulatta, Orbitofrontal cortex, Visual category discrimination, Single neuron activity, Microiontophoresis

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Abstract

Orbitofrontal cortex (OBF) plays important role in the organization of adaptive behavior. To characterize these functions, single neuron activity was recorded in rhesus monkey OBF 1) during feeding or sexually motivated visual category discrimination tasks and 2) microiontophoresis of neuroactive substances (e.g. glucose, dopamine). The effect of fasting signals on task performance was also tested. Specific feeding- and sex-related firing rate changes were found. OBF neurons showed wide variety of task or category selectivity. Reward- and expectation-related activities were also recorded. In addition, OBF neurons showed complex chemosensitivity to microiontophoretically administered chemicals. Task performance was improved by the i.m. injected fasting-induced endogenous substance 2-buten-4-olide. Our results revealed that OBF is one of the key centers in the organization of adaptive behavior by integrating endo- and exogenous information both on the neurochemical and cognitive level. Supported by Grants-in-Aid for Scientific Research (S.A.), 21st Century COE Program, NRF and HSC of Hungary (T042721, M036687, ETT 315/ and 317/2006), NKTH-RET 008/2005 MEDIPOLIS and Hungarian Academy of Sciences. [J Physiol Sci. 2008;58 Suppl:S147]

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