DIFFERENTIAL EFFECTS OF CHLORPROMAZINE UPON PASSIVE AVOIDANCE RESPONSE IN RATS UNDER TWO TYPES OF SHOCK TREATMENT

TSUNEO IWASAKI; MITSUKO KATAYAMA; SHINKURO IWAHARA

doi:10.4992/psycholres1954.10.191

TSUNEO IWASAKI, MITSUKO KATAYAMA, SHINKURO IWAHARA

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JOURNAL FREE ACCESS

1968 Volume 10 Issue 4 Pages 191-198

DOI https://doi.org/10.4992/psycholres1954.10.191

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Published: 1968 Received: October 04, 1968 Available on J-STAGE: February 24, 2009 Accepted: - Advance online publication: - Revised: -
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Date of correction: February 24, 2009 Reason for correction: - Correction: ABSTRACT Details: Wrong : Chlorpromazine at 2 mg/kg, i. p. was shown to inhibit the rat's passive avoidance response in a two-compartment apparatus when the rat was given unescapable electric shock, being confined in the small compartment, while the same effect failed to appear when the rat, placed in the large compartment, received electric shock only upon attempting to enter the small compartment and thus the shock was escapable. A slight but nonsignificant drug-learning dissociation appeared in the “confinement shock” rat. 17 min after the two-compartment training, the rat was observed spontaneous activities in an open-field but no clear-cut differences were found between two types of shock treatment, or between saline and chlorpromazine medication.
Right : Chlorpromazine at 2mg/kg, i.p. was shown to inhibit the rat's passive avoidance response in a two-compartment apparatus when the rat was given unescapable electric shock, being confined in the small compartment, while the same effect failed to appear when the rat, placed in the large compartment, received electric shock only upon attempting to enter the small compartment and thus the shock was escapable. A slight but nonsignificant drug-learning dissociation appeared in the “confinement shock” rat. 17 min after the two-compartment training, the rat was observed spontaneous activities in an open-field but no clear-cut differences were found between two types of shock treatment, or between saline and chlorpromazine medication.

Date of correction: February 24, 2009 Reason for correction: - Correction: CITATION Details: Wrong : BRIMBLECOMBE, R. W. 1963 Effects of psychotropic drugs on open-field behaviour in rats. Psychopharmacologia, 4, 139-147.
BUREŠ, J., & BUREŠOVÁ, O. 1963 Cortical spreading depression as a memory disturbing factor. J. comp. physiol. Psychol., 56, 268-272.
CHOROVER, S. L., & SCHILLER, P. H. 1966 Reexamination of prolonged retrograde amnesia in one-trial learning. J. comp. physiol. Psychol., 61, 34-41.
IWAHARA, S., IWASAKI, T., & HASEGAWA, Y. 1968 Effects of chlorpromazine and homofenazine upon a passive avoidance response in rats. Psychopharmacologia, 13, 320-331.
OTIS, L. S. 1964 Dissociation and recovery of a response learned under the influence of chlorpromazine or saline. Science, 140, 1347-1348.
OVERTON, D. A. 1966 State-dependent learning produced by depressant and atropine-like drugs. Psychopharmacologia, 10, 6-31.
STEWART, J. 1962 Differential response based on the physiological consequences of pharmacological agents. Psychopharmacologia, 3, 132-138.

Right : BRIMBLECOMBE, R. W. 1963 Effects of psychotropic drugs on open-field behaviour in rats. Psychopharmacologia, 4, 139-147.
BUREŠ, J., & BUREŠOVÁ, O. 1963 Cortical spreading depression as a memory disturbing factor. J. comp. physiol. Psychol., 56, 268-272.
CHOROVER, S. L., & SCHILLER, P. H. 1966 Reexamination of prolonged retrograde amnesia in one-trial learning. J. comp. physiol. Psychol., 61, 31-11.
IWAHARA, S., IWASAKI, T., & HASEGAWA, Y. 1968 Effects of chlorpromazine and homofenazine upon a passive avoidance response in rats. Psychopharmacologia, 13, 320-331.
OTIS, L. S. 1964 Dissociation and recovery of a response learned under the influence of chlor-promazine or saline. Science, 140, 1347-1348.
OVERTON, D. A. 1966 State-dependent learning produced by depressant and atropine-like drugs. Psychopharmacologia, 10, 6-31.
STEWART, J. 1962 Differential response based on the physiological consequences of pharmacological agents. Psychopharmacologia, 3, 132-138.

Date of correction: February 24, 2009 Reason for correction: - Correction: PDF FILE Details: -

Date of correction: February 24, 2009 Reason for correction: - Correction: CITATION Details: Wrong : BRIMBLECOMBE, R. W. 1963 Effects of psychotropic drugs on open-field behaviour in rats. Psychopharmacologia, 4, 139-147.
BUREŠ, J., & BUREŠOVÁ, O. 1963 Cortical spreading depression as a memory disturbing factor. J. comp. physiol. Psychol., 56, 268-272.
CHOROVER, S. L., & SCHILLER, P. H. 1966 Reexamination of prolonged retrograde amnesia in one-trial learning. J. comp. physiol. Psychol., 61, 31-11.
IWAHARA, S., IWASAKI, T., & HASEGAWA, Y. 1968 Effects of chlorpromazine and homofenazine upon a passive avoidance response in rats. Psychopharmacologia, 13, 320-331.
OTIS, L. S. 1964 Dissociation and recovery of a response learned under the influence of chlor-promazine or saline. Science, 140, 1347-1348.
OVERTON, D. A. 1966 State-dependent learning produced by depressant and atropine-like drugs. Psychopharmacologia, 10, 6-31.
STEWART, J. 1962 Differential response based on the physiological consequences of pharmacological agents. Psychopharmacologia, 3, 132-138.

Right : BRIMBLECOMBE, R. W. 1963 Effects of psychotropic drugs on open-field behaviour in rats. Psychopharmacologia, 4, 139-147.
BUREŠ, J., & BUREŠOVÁ, O. 1963 Cortical spreading depression as a memory disturbing factor. J. comp. physiol. Psychol., 56, 268-272.
CHOROVER, S. L., & SCHILLER, P. H. 1966 Reexamination of prolonged retrograde amnesia in one-trial learning. J. comp. physiol. Psychol., 61, 34-41.
IWAHARA, S., IWASAKI, T., & HASEGAWA, Y. 1968 Effects of chlorpromazine and homofenazine upon a passive avoidance response in rats. Psychopharmacologia, 13, 320-331.
OTIS, L. S. 1964 Dissociation and recovery of a response learned under the influence of chlorpromazine or saline. Science, 140, 1347-1348.
OVERTON, D. A. 1966 State-dependent learning produced by depressant and atropine-like drugs. Psychopharmacologia, 10, 6-31.
STEWART, J. 1962 Differential response based on the physiological consequences of pharmacological agents. Psychopharmacologia, 3, 132-138.

Abstract

Chlorpromazine at 2mg/kg, i.p. was shown to inhibit the rat's passive avoidance response in a two-compartment apparatus when the rat was given unescapable electric shock, being confined in the small compartment, while the same effect failed to appear when the rat, placed in the large compartment, received electric shock only upon attempting to enter the small compartment and thus the shock was escapable. A slight but nonsignificant drug-learning dissociation appeared in the “confinement shock” rat. 17 min after the two-compartment training, the rat was observed spontaneous activities in an open-field but no clear-cut differences were found between two types of shock treatment, or between saline and chlorpromazine medication.

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