EFFECTS OF FUNCTIONAL DISTURBANCES OF THE LIMBIC SYSTEM ON THE MEMORY CONSOLIDATION

TOSHITSUGU HIRANO

doi:10.4992/psycholres1954.7.171

TOSHITSUGU HIRANO

Author information

JOURNAL FREE ACCESS

1965 Volume 7 Issue 4 Pages 171-182

DOI https://doi.org/10.4992/psycholres1954.7.171

Details

Published: 1965 Received: November 22, 1965 Available on J-STAGE: February 24, 2009 Accepted: - Advance online publication: - Revised: -
Correction information
Date of correction: February 24, 2009 Reason for correction: - Correction: ABSTRACT Details: Wrong : In order to see the effects of functional disturbances of the limbic system on memo-ry consolidation, several experiments were performed. In part 1, the limbic seizure was produced by hippocampal electrical stimulation after a training trial and the results were compared to the treatment of the electroconvulsive shock. In part 2, solutions of potassium chloride or calcium chloride were injected into the reticular formation and the hippocampus after a trial, or prior to the training. The im-pairment was most severe when the ECS was given after a daily trial. But injec-tion of calcium chloride or potassium chlo-ride into the hippocampus was followed markedly by the decremental effect of the retention. In the single-shock experiment, seizure of all neurons in the brain is not required to produce retrograde amnesia. The functional disturbances of the hip-pocampal area had a similar effect as the convulsions produced by ECS, so long as a passive avoidance test was performed. The results were discussed in terms of the reduction of reactive inhibition. When daily injections were continued, Ss receiving injections in the reticular formation showed more retardation or impairment of maze learning or active avoidance compared to Ss receiving hippocampal injection. It was suggested that disturbances of the reticular formation might disrupt the acquisition of the learning, by an inhibitory mechanism which develops cumulatively.
Right : To see the effects of functional disturbances of the limbic system on memory consolidation, several experiments were performed in rats. In part I, the limbic seizure was produced by hippocampal electrical stimulation 1 min after a training trial, and the results were compared to Ss with ECS. In part 2, KCl or Ca was injected into reticular formation or hippocampus. The result indicated that the functional disturbances of the hippocampal area had a similar effect as ECS in a passive avoidance. When daily treatments were continued, Ss with ECS showed severe retardation in maze learning. Ss receiving injections in the reticular formation showed more retardation in both maze learning and active avoidance in comparison with Ss receiving hippocampal injection.

Date of correction: February 24, 2009 Reason for correction: - Correction: CITATION Details: Wrong : ALEXANDER, H. W. 1946 A general test for trend. Psychol. Bull., 43, 533-561.
DEGROOT, J. 1959 The rat forebrain in stereo-taxic coordinates. Verh. Kon. Ned. Wet., B Naturekunde, 52, 1-40.
DOTY, B. A. & DOTY, L.A. 1964 Effect of age and chlorpromazine on memory consolida-tion. J. comp. physiol. Psychol., 57, 331-334.
DUNOAN, C. P. 1949 The retroactive effect of electroconvulsive shock on learning. J. comp. physiol. Psychol., 42, 32-44.
LEUKEL, F. A. 1957 A comparison of the effects of ECS and anesthesia on acquisition of the maze habit. J. comp. physiol. Psychol., 50, 300-306.
LIEBERMAN, G. J. & OWEN, D. B. 1961 Tables of the hypergeometric probability distribution. Stan-ford: Stanford Univ. Press.
NAKAJIMA, S. 1964 Effects of chemical injection into the reticular formation of rats. J. comp. physiol. Psychol., 58, 10-15.
PEARLMAN, C. A., SHARPLESS, S. K., & JARVIK, M. E. 1961 Retrograde amnesia produced by anesthetic and convulsant agents. J. comp. physiol. Psychol., 54, 109-112.
THOMPSON, R. 1957 The comparative effects of ECS and anoxia on memory. J. comp, physiol. Psychol., 50, 397-400.
THOMPSON, R. 1958 The effect of intracranial stimulation on memory in cats. J. comp. physiol. Psychol., 51, 421-426.
VANDERWOLF, C. H. 1963 Improved shuttle-box performance following electroconvulsive shock. J. comp. physiol. Psychol., 56, 983-986.
WEISSMAN, A. 1963 Effect of electroconvulsive shock intensity and seizure pattern on retro-grade amnesia in rats. J. comp. physiol. Psychol., 56, 806-810.

Right : ALEXANDER, H. W. 1946 A general test for trend. Psychol. Bull., 43, 533-561.
DEGROOT, J. 1959 The rat forebrain in stereotaxic coordinates. Verh. Kon. Ned. Wet., B Naturekunde, 52, 1-40.
DOTY, B. A. & DOTY, L. A. 1964 Effect of age and chlorpromazine on memory consolidation. J. comp. physiol. Psychol., 57, 331-334.
DUNCAN, C. P. 1949 The retroactive effect of electroconvulsive shock on learning. J. comp. physiol. Psychol., 42, 32-44.
LEUKEL, F. A. 1957 A comparison of the effects of ECS and anesthesia on acquisition of the maze habit. J. comp. physiol. Psychol., 50, 300-306.
LIEBERMAN, G. J. & OWEN, D. B. 1961 Tables of the hypergeometric probability distribution. Stanford: Stanford Univ. Press.
NAKAJIMA, S. 1964 Effects of chemical injection into the reticular formation of rats. J. comp. physiol. Psychol., 58, 10-15.
PEARLMAN, C. A., SHARPLESS, S. K., & JARVIK, M. E. 1961 Retrograde amnesia produced by anesthetic and convulsant agents. J. comp. physiol. Psychol., 54, 109-112.
THOMPSON, R. 1957 The comparative effects of ECS and anoxia on memory. J. comp. physiol. Psychol., 50, 397-400.
THOMPSON, R. 1958 The effect of intracranial stimulation on memory in cats. J. comp. physiol. Psychol., 51, 421-426.
VANDERWOLF, C. H. 1963 Improved shuttle-box performance following electroconvulsive shock. J. comp. physiol. Psychol., 56, 983-986.
WEISSMAN, A. 1963 Effect of electroconvulsive shock intensity and seizure pattern on retrograde amnesia in rats. J. comp. physiol. Psychol., 56, 806-810.

Date of correction: February 24, 2009 Reason for correction: - Correction: PDF FILE Details: -

Date of correction: February 24, 2009 Reason for correction: - Correction: ABSTRACT Details: Wrong : To see the effects of functional disturbances of the limbic system on memory consolidation, several experiments were performed in rats. In part I, the limbic seizure was produced by hippocampal electrical stimulation 1 min after a training trial, and the results were compared to Ss with ECS. In part 2, KCl or Ca was injected into reticular formation or hippocampus. The result indicated that the functional disturbances of the hippocampal area had a similar effect as ECS in a passive avoidance. When daily treatments were continued, Ss with ECS showed severe retardation in maze learning. Ss receiving injections in the reticular formation showed more retardation in both maze learning and active avoidance in comparison with Ss receiving hippocampal injection.
Right : To see the effects of functional disturbances of the limbic system on memory consolidation, several experiments were performed in rats. In part 1, the limbic seizure was produced by hippocampal electrical stimulation 1 min after a training trial, and the results were compared to Ss with ECS. In part 2, KCl or Ca was injected into reticular formation or hippocampus. The result indicated that the functional disturbances of the hippocampal area had a similar effect as ECS in a passive avoidance. When daily treatments were continued, Ss with ECS showed severe retardation in maze learning. Ss receiving injections in the reticular formation showed more retardation in both maze learning and active avoidance in comparison with Ss receiving hippocampal injection.

Abstract

To see the effects of functional disturbances of the limbic system on memory consolidation, several experiments were performed in rats. In part 1, the limbic seizure was produced by hippocampal electrical stimulation 1 min after a training trial, and the results were compared to Ss with ECS. In part 2, KCl or Ca was injected into reticular formation or hippocampus. The result indicated that the functional disturbances of the hippocampal area had a similar effect as ECS in a passive avoidance. When daily treatments were continued, Ss with ECS showed severe retardation in maze learning. Ss receiving injections in the reticular formation showed more retardation in both maze learning and active avoidance in comparison with Ss receiving hippocampal injection.

Corresponding author

Correction information

Register with J-STAGE for free!