RESPONSE PERSEVERATION FOLLOWING THE HIPPOCAMPAL ABLATION IN THE RAT

HIROAKI NIKI

doi:10.4992/psycholres1954.8.1

HIROAKI NIKI

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JOURNAL FREE ACCESS

1966 Volume 8 Issue 1 Pages 1-9

DOI https://doi.org/10.4992/psycholres1954.8.1

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Published: 1966 Received: October 11, 1965 Available on J-STAGE: February 24, 2009 Accepted: - Advance online publication: - Revised: -
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Date of correction: February 24, 2009 Reason for correction: - Correction: CITATION Details: Wrong : BOURKE, W. T. 1954 The effects of frontal lobe damage upon habit reversal in the white rat. J. comp. physiol. Psychol., 47, 277-282.
CLARK, C. V. H., & ISAACSON, R. L. 1965 Effect of hippocampal ablation on DRL performance., J. comp. physiol. Psychol., 59, 137-140.
DASHIELL, J. F. 1930 Direction orientation in maze running by the white rat. Comp. Psychol. Monogr., 7, 1-72.
DOUGLAS, R. J., & ISAACSON, R. L. 1964 Hippo campal lesions and activity. Psychon. Sci., 1, 187-188.
ELLEN, P., & WILSON, A. S. 1963 Perseveration in the rat following hippocampal lesions. Exp. Neurol., 8, 310-317.
GROSS, C. G., CHOROVER, S. T., & COHEN, S. M. 1965 Caudate, cortical, hippocampal and dorsal thalamic lesions in rats: Alternation and Hebb-Williams maze performance. Neuropsychologia, 3, 53-68.
ISAACSON, R. L., DOUGLAS, R. J., & MOORE, R. Y. 1961 The effect of radical hippocampal ablation on acquisition of avoidance response., J. comp. physiol. Psychol., 54, 625-628.
ISAACSON, R. L., & WICKELGREN, W. O. 1962 Hippocampal ablation and passive avoidance. Science, 138, 1104-1106.
JARRARD, L. E. 1965 Hippocampal ablation and operant behavior in the rat. Psychon. Sci., 2, 115-116.
JARRARD, L. E., ISAACSON, R. L., & WIKELGREN, W. O. 1964 Effects of hippocampal ablation and intertrial interval on runway acquisition and extinction., J. comp. physiol. Psychol., 57, 442-444.
KAADA, B. R., RASMUSSEN, E. W., & KVEIM, O. 1961 Effects of hippocampal lesions on maze learning and retention in rats. Exp. Neurol., 3, 333-355.
KIMBLE, D. P. 1963 The effects of bilateral hippocampal lesions in rats., J. comp. physiol. Psychol., 56, 273-283.
KIMURA, D. 1958 Effects of selective hippo-campal damage on avoidance behavior of the rat. Can. J. Psychol., 12, 213-217.
KVEIM, O., SETEKLEIV, J., & KAADA, B. R. 1964 Differential effects of hippocampal lesions on maze and passive avoidance learning in rats. Exp. Neurol., 9, 59-72.
LASH, L. 1964 Response discriminability and the hippocampus., J. comp. physiol. Psychol., 46, 251-256.
KRECHEVSKY, I. 1937 Brain mechanisms and variability: I. Variability within a meansend-readiness., J. comp. Psychol., 23, 121-138.
MAHUT, H., & CORDEAU, J. P. 1963 Spatial reversal deficit in monkeys with amygdalohippocampal ablations. Exp. Neural., 7, 426-434.
NIKI, H. 1962 The effects of hippocampal ablation on the behavior in the rat., Jap. psychol. Res., 4, 139-153.
NIKI, H. 1965 The effects of hippocampal ablation on the inhibitory control of operant behavior in the rat., Jap. psychol. Res., 7, 126-137.
ORBACH, J., MILNER, B., & RASMUSSEN, T. 1960 Learning and retention in monkeys after amygdala-hippocampus resection. A. M. A. Arch. Neural., 3, 230-251.
ROBERTS, W. W., DEMBER, W. N., & BRODWICK, M. 1962 Alternation and exploration in rats with hippocampal lesions., J. comp. physiol. Psychol., 55, 695-700.
SETTLAGE, P., ZABLE, M., & HARLOW, H. F. 1948 Problem solution by monkeys following bilateral removal of the prefrontal areas: VI. Performance on tests requiring contradictory reactions to similar and to identical stimuli. J. exp. Psychol., 38, 30-65.
SIEGEL, S. 1956 Nonparametrie statistics for the behavioral sciences. New York: McGraw Hill.
STEPIEN, L. S., CORDEAU, J. P., & RASMUSSEN, T. 1960 The effect of temporal lobe and hippocampal lesions on auditory and visual recent memory in monkeys. Brain, 83, 470-489.
TEITELBAUM, H. 1964 A comparison of effects of orbitofrontal and hippocampal lesions upon discrimination learning and reversal in the cat. Exp. Neurol., 9, 452-462.
THOMAS, G. J., & OTIS, L. S. 1958 Effects of rhinencephalic lesions on maze learning in rats. J. comp. physiol. Psychol., 51, 161-166.
THOMPSON, R., & LANGER, S. K. 1963 Deficits in position reversal learning following lesions of the limbic system., J. comp. physiol. Psychol., 56, 987-995.
WARREN, J. M., WARREN, H. B., & AKERT, K. 1962 Orbitofrontal cortical lesions and learning in cats. J. comp. Neurol., 118, 17-42.

Right : BOURKE, W. T. 1954 The effects of frontal lobe damage upon habit reversal in the white rat. J. comp. physiol. Psychol., 47, 277-282.
CLARK, C. V. H., & ISAACSON, R. L. 1965 Effect of hippocampal ablation on DRL performance. J. comp. physiol. Psychol., 59, 137-140.
DASHIELL, J. F. 1930 Direction orientation in maze running by the white rat. Comp. Psychol. Monogr., 7, 1-72.
DOUGLAS, R. J., & ISAACSON, R. L. 1964 Hippocampal lesions and activity. Psychon. Sci., 1, 187-188.
ELLEN, P., & WILSON, A. S. 1963 Perseveration in the rat following hippocampal lesions. Exp. Neurol., 8, 310-317.
GROSS, C. G., CHOROVER, S. T., & COHEN, S. M. 1965 Caudate, cortical, hippocampal and dorsal thalamic lesions in rats: Alternation and Hebb-Williams maze performance. Neuropsychologia, 3, 53-68.
ISAACSON, R. L., DOUGLAS, R. J., & MOORE, R. Y. 1961 The effect of radical hippocampal ablation on acquisition of avoidance response. J. comp. physiol. Psychol., 54, 625-628.
ISAACSON, R. L., & WICKELGREN, W. O. 1962 Hippocampal ablation and passive avoidance. Science, 138, 1104-1106.
JARRARD, L. E. 1965 Hippocampal ablation and operant behavior in the rat. Psychon. Sci., 2, 115-116.
JARRARD, L. E., ISAACSON, R. L., & WIKELGREN, W. O. 1964 Effects of hippocampal ablation and intertrial interval on runway acquisition and extinction. J. comp. physiol. Psychol., 57, 442-444.
KAADA, B. R., RASMUSSEN, E. W., & KVEIM, O. 1961 Effects of hippocampal lesions on maze learning and retention in rats. Exp. Neurol., 3, 333-355.
KIMBLE, D. P.1963 The effects of bilateral hippocampal lesions in rats. J. comp. physiol. Psychol., 56, 273-283.
KIMURA, D. 1958 Effects of selective hippocampal damage on avoidance behavior of the rat. Gan. J. Psychol., 12, 213-217.
KVEIM, O., SETEKLEIV, J., & KAADA, B. R. 1964 Differential effects of hippocampal lesions on maze and passive avoidance learning in rats. Exp. Neurol., 9, 59-72.
LASH, L. 1964 Response discriminability and the hippocampus. J. comp. physiol. Psychol., 46, 251-256.
KRECHEVSKY, I. 1937 Brain mechanisms and variability: I. Variability within a meansend-readiness. J. comp. Psychol., 23, 121-138.
MAHUT, H., & CORDEAU, J. P. 1963 Spatial reversal deficit in monkeys with amygdalohippocarnpal ablations. Exp. Neural., 7, 426-434.
NIKI, H. 1962 The effects of hippocampal ablation on the behavior in the rat. Jap. psychol. Res., 4, 139-153.
NIKI, H. 1965 The effects of hippocampal ablation on the inhibitory control of operant behavior in the rat. Jap. psychol. Res., 7, 126-137.
ORBACH, J., MILNER, B., & RASMUSSEN, T. 1960 Learning and retention in monkeys after amygdala-hippocampus resection. A. M. A. Arch. Neurol., 3, 230-251.
ROBERTS, W. W., DEMBER, W. N., & BRODWICK, M. 1962 Alternation and exploration in rats with hippocampal lesions. J. comp. physiol. Psychol., 55, 695-700.
SETTLAGE, P., ZABLE, M., & HARLOW, H. F. 1948 Problem solution by monkeys following bilateral removal of the prefrontal areas: VI. Performance on tests requiring contradictory reactions to similar and to identical stimuli. J. exp. Psychol., 38, 30-65.
SIEGEL, S. 1956 Nonparametric statistics for the behavioral sciences. New York: McGraw Hill.
STEPIEN, L. S., CORDEAU, J. P., & RASMUSSEN, T. 1960 The effect of temporal lobe and hippocarnpal lesions on auditory and visual recent memory in monkeys. Brain, 83, 470-489.
TEITELBAUM, H. 1964 A comparison of effects of orbitofrontal and hippocampal lesions upon discrimination learning and reversal in the cat. Exp. Neurol., 9, 452-462.
THOMAS, G. J., & OTIS, L. S. 1958 Effects of rhinencephalic lesions on maze learning in rats. J. comp. physiol. Psychol., 51, 161-166.
THOMPSON, R., & LANGER, S. K. 1963 Deficits in position reversal learning following lesions of the limbic system. J. comp. physiol. Psychol., 56, 987-995.
WARREN, J. M., WARREN, H. B., & AKERT, K. 1962 Orbitofrontal cortical lesions and learning in cats. J. comp. Neurol., 118, 17-42.

Date of correction: February 24, 2009 Reason for correction: - Correction: PDF FILE Details: -

Date of correction: February 24, 2009 Reason for correction: - Correction: CITATION Details: Wrong : BOURKE, W. T. 1954 The effects of frontal lobe damage upon habit reversal in the white rat. J. comp. physiol. Psychol., 47, 277-282.
CLARK, C. V. H., & ISAACSON, R. L. 1965 Effect of hippocampal ablation on DRL performance. J. comp. physiol. Psychol., 59, 137-140.
DASHIELL, J. F. 1930 Direction orientation in maze running by the white rat. Comp. Psychol. Monogr., 7, 1-72.
DOUGLAS, R. J., & ISAACSON, R. L. 1964 Hippocampal lesions and activity. Psychon. Sci., 1, 187-188.
ELLEN, P., & WILSON, A. S. 1963 Perseveration in the rat following hippocampal lesions. Exp. Neurol., 8, 310-317.
GROSS, C. G., CHOROVER, S. T., & COHEN, S. M. 1965 Caudate, cortical, hippocampal and dorsal thalamic lesions in rats: Alternation and Hebb-Williams maze performance. Neuropsychologia, 3, 53-68.
ISAACSON, R. L., DOUGLAS, R. J., & MOORE, R. Y. 1961 The effect of radical hippocampal ablation on acquisition of avoidance response. J. comp. physiol. Psychol., 54, 625-628.
ISAACSON, R. L., & WICKELGREN, W. O. 1962 Hippocampal ablation and passive avoidance. Science, 138, 1104-1106.
JARRARD, L. E. 1965 Hippocampal ablation and operant behavior in the rat. Psychon. Sci., 2, 115-116.
JARRARD, L. E., ISAACSON, R. L., & WIKELGREN, W. O. 1964 Effects of hippocampal ablation and intertrial interval on runway acquisition and extinction. J. comp. physiol. Psychol., 57, 442-444.
KAADA, B. R., RASMUSSEN, E. W., & KVEIM, O. 1961 Effects of hippocampal lesions on maze learning and retention in rats. Exp. Neurol., 3, 333-355.
KIMBLE, D. P.1963 The effects of bilateral hippocampal lesions in rats. J. comp. physiol. Psychol., 56, 273-283.
KIMURA, D. 1958 Effects of selective hippocampal damage on avoidance behavior of the rat. Gan. J. Psychol., 12, 213-217.
KVEIM, O., SETEKLEIV, J., & KAADA, B. R. 1964 Differential effects of hippocampal lesions on maze and passive avoidance learning in rats. Exp. Neurol., 9, 59-72.
LASH, L. 1964 Response discriminability and the hippocampus. J. comp. physiol. Psychol., 46, 251-256.
KRECHEVSKY, I. 1937 Brain mechanisms and variability: I. Variability within a meansend-readiness. J. comp. Psychol., 23, 121-138.
MAHUT, H., & CORDEAU, J. P. 1963 Spatial reversal deficit in monkeys with amygdalohippocarnpal ablations. Exp. Neural., 7, 426-434.
NIKI, H. 1962 The effects of hippocampal ablation on the behavior in the rat. Jap. psychol. Res., 4, 139-153.
NIKI, H. 1965 The effects of hippocampal ablation on the inhibitory control of operant behavior in the rat. Jap. psychol. Res., 7, 126-137.
ORBACH, J., MILNER, B., & RASMUSSEN, T. 1960 Learning and retention in monkeys after amygdala-hippocampus resection. A. M. A. Arch. Neurol., 3, 230-251.
ROBERTS, W. W., DEMBER, W. N., & BRODWICK, M. 1962 Alternation and exploration in rats with hippocampal lesions. J. comp. physiol. Psychol., 55, 695-700.
SETTLAGE, P., ZABLE, M., & HARLOW, H. F. 1948 Problem solution by monkeys following bilateral removal of the prefrontal areas: VI. Performance on tests requiring contradictory reactions to similar and to identical stimuli. J. exp. Psychol., 38, 30-65.
SIEGEL, S. 1956 Nonparametric statistics for the behavioral sciences. New York: McGraw Hill.
STEPIEN, L. S., CORDEAU, J. P., & RASMUSSEN, T. 1960 The effect of temporal lobe and hippocarnpal lesions on auditory and visual recent memory in monkeys. Brain, 83, 470-489.
TEITELBAUM, H. 1964 A comparison of effects of orbitofrontal and hippocampal lesions upon discrimination learning and reversal in the cat. Exp. Neurol., 9, 452-462.
THOMAS, G. J., & OTIS, L. S. 1958 Effects of rhinencephalic lesions on maze learning in rats. J. comp. physiol. Psychol., 51, 161-166.
THOMPSON, R., & LANGER, S. K. 1963 Deficits in position reversal learning following lesions of the limbic system. J. comp. physiol. Psychol., 56, 987-995.
WARREN, J. M., WARREN, H. B., & AKERT, K. 1962 Orbitofrontal cortical lesions and learning in cats. J. comp. Neurol., 118, 17-42.

Right : BOURKE, W. T. 1954 The effects of frontal lobe damage upon habit reversal in the white rat. J. comp. physiol. Psychol., 47, 277-282.
CLARK, C. V. H., & ISAACSON, R. L. 1965 Effect of hippocampal ablation on DRL performance. J. comp. physiol. Psychol., 59, 137-140.
DASHIELL, J. F. 1930 Direction orientation in maze running by the white rat. Comp. Psychol. Monogr., 7, 1-72.
DOUGLAS, R. J., & ISAACSON, R. L. 1964 Hippocampal lesions and activity. Psychon. Sci., 1, 187-188.
ELLEN, P., & WILSON, A. S. 1963 Perseveration in the rat following hippocampal lesions. Exp. Neurol., 8, 310-317.
GROSS, C. G., CHOROVER, S. T., & COHEN, S. M. 1965 Caudate, cortical, hippocampal and dorsal thalamic lesions in rats: Alternation and Hebb-Williams maze performance. Neuropsychologia, 3, 53-68.
ISAACSON, R. L., DOUGLAS, R. J., & MOORE, R. Y. 1961 The effect of radical hippocampal ablation on acquisition of avoidance response. J. comp. physiol. Psychol., 54, 625-628.
ISAACSON, R. L., & WICKELGREN, W. O. 1962 Hippocampal ablation and passive avoidance. Science, 138, 1104-1106.
JARRARD, L. E. 1965 Hippocampal ablation and operant behavior in the rat. Psychon. Sci., 2, 115-116.
JARRARD, L. E., ISAACSON, R. L., & WIKELGREN, W. O. 1964 Effects of hippocampal ablation and intertrial interval on runway acquisition and extinction. J. comp. physiol. Psychol., 57, 442-444.
KAADA, B. R., RASMUSSEN, E. W., & KVEIM, O. 1961 Effects of hippocampal lesions on maze learning and retention in rats. Exp. Neurol., 3, 333-355.
KIMBLE, D. P. 1963 The effects of bilateral hippocampal lesions in rats. J. comp. physiol. Psychol., 56, 273-283.
KIMURA, D. 1958 Effects of selective hippocampal damage on avoidance behavior of the rat. Gan. J. Psychol., 12, 213-217.
KVEIM, O., SETEKLEIV, J., & KAADA, B. R. 1964 Differential effects of hippocampal lesions on maze and passive avoidance learning in rats. Exp. Neurol., 9, 59-72.
LASH, L. 1964 Response discriminability and the hippocampus. J. comp. physiol. Psychol., 46, 251-256.
KRECHEVSKY, I. 1937 Brain mechanisms and variability: I. Variability within a meansend-readiness. J. comp. Psychol., 23, 121-138.
MAHUT, H., & CORDEAU, J. P. 1963 Spatial reversal deficit in monkeys with amygdalohippocampal ablations. Exp. Neural., 7, 426-434.
NIKI, H. 1962 The effects of hippocampal ablation on the behavior in the rat. Jap. psychol. Res., 4, 139-153.
NIKI, H. 1965 The effects of hippocampal ablation on the inhibitory control of operant behavior in the rat. Jap. psychol. Res., 7, 126-137.
ORBACH, J., MILNER, B., & RASMUSSEN, T. 1960 Learning and retention in monkeys after amygdala-hippocampus resection. A. M. A. Arch. Neurol., 3, 230-251.
ROBERTS, W. W., DEMBER, W. N., & BRODWICK, M. 1962 Alternation and exploration in rats with hippocampal lesions. J. comp. physiol. Psychol., 55, 695-700.
SETTLAGE, P., ZABLE, M., & HARLOW, H. F. 1948 Problem solution by monkeys following bilateral removal of the prefrontal areas: VI. Performance on tests requiring contradictory reactions to similar and to identical stimuli. J. exp. Psychol., 38, 30-65.
SIEGEL, S. 1956 Nonparametric statistics for the behavioral sciences. New York: McGraw Hill.
STEPIEN, L. S., CORDEAU, J. P., & RASMUSSEN, T. 1960 The effect of temporal lobe and hippocampal lesions on auditory and visual recent memory in monkeys. Brain, 83, 470-489.
TEITELBAUM, H. 1964 A comparison of effects of orbitofrontal and hippocampal lesions upon discrimination learning and reversal in the cat. Exp. Neurol., 9, 452-462.
THOMAS, G. J., & OTIS, L. S. 1958 Effects of rhinencephalic lesions on maze learning in rats. J. comp. physiol. Psychol., 51, 161-166.
THOMPSON, R., & LANGER, S. K. 1963 Deficits in position reversal learning following lesions of the limbic system. J. comp. physiol. Psychol., 56, 987-995.
WARREN, J. M., WARREN, H. B., & AKERT, K. 1962 Orbitofrontal cortical lesions and learning in cats. J. comp. Neurol., 118, 17-42.

Abstract

In comparison with neocortically ablated animals, the hippocampally ablated animals were severely impaired in position reversal and single alternation learning. The hippocampally ablated animals showed less flexibility of solutions as revealed in the decreased number of different paths chosen and the decreased number of shifts in a Dashiell maze. With respect to response shift the cortically ablated and sham-operated animals manifested an obvious tendency to avoid the preceding forced turns while the hippocampally ablated animals were found to perseverate. These results suggest that hippocampal ablation produced an obvious tendency toward response perseveration.

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