Abstract
In Northern Kazakhstan, there are uranium processing facilities, depleted uranium mines, and radioactive waste storage facilities. The project goal is to investigate the impact of technogenic radiation factors on the development of tumor and non-tumor bronchopulmonary diseases in the population of Northern Kazakhstan based on molecular-genetic analysis. Based on the obtained data on the radioecological situation, probable dose load will be calculated, and the risk of bronchopulmonary diseases in the population will be assessed. For the first time, the presence of polymorphisms in genes ERCC1 (rs11615, rs3212986), ERCC2 (rs13181), OGG1 (rs1052133), ABL2 rs117218074, SMARCA4 rs2288845, PIK3R2 rs142933317, MAPK1 rs1803545, (CHD4) rs74790047, and TSC2 rs2121870 will be studied in lung cancer patients exposed to radon, radiation risk factors for development of oncopathology in the population. Considering the synthesis and analysis of study results, measures will be developed to reduce technogenic and radiation risks of bronchopulmonary diseases for the population living near the storage facilities for radioactive waste and decommissioned mines in Northern Kazakhstan.
