【99m】Tc-N- (2, 6ジエチルフェニルカルバモイルメチル) イミノニ酢酸 (EHIDA) 肝胆道シンチグラフィによる慢性肝疾患における胆嚢収縮能の検討

栗原 教光; 井手 宏; 小俣 武; 与那嶺 茂道; 間島 寧興; 丹野 宗彦; 千葉 一夫; 山田 英夫

doi:10.3769/radioisotopes.38.6_269

Evaluation of Gallbladder Emptying in Patients with Chronic Liver Disease by ^99mTc-EHIDA Hepatobiliary Scintigraphy

Norimitsu KURIHARA, Hiroshi IDE, Takeshi OMATA, Shigemichi YONAMINE, Yasuoki MASHIMA, Munehiko TANNO, Kazuo CHIBA, Hideo YAMADA

Author information

Norimitsu KURIHARA
Department of Nuclear Medicine and Radiological Sciences, Tokyo Metropolitan Geriatric Hospital
Hiroshi IDE
Department of Nuclear Medicine and Radiological Sciences, Tokyo Metropolitan Geriatric Hospital
Takeshi OMATA
Department of Nuclear Medicine and Radiological Sciences, Tokyo Metropolitan Geriatric Hospital
Shigemichi YONAMINE
Department of Nuclear Medicine and Radiological Sciences, Tokyo Metropolitan Geriatric Hospital
Yasuoki MASHIMA
Department of Nuclear Medicine and Radiological Sciences, Tokyo Metropolitan Geriatric Hospital
Munehiko TANNO
Department of Nuclear Medicine and Radiological Sciences, Tokyo Metropolitan Geriatric Hospital
Kazuo CHIBA
Department of Nuclear Medicine and Radiological Sciences, Tokyo Metropolitan Geriatric Hospital
Hideo YAMADA
Department of Nuclear Medicine and Radiological Sciences, Tokyo Metropolitan Geriatric Hospital

Keywords: hepatobiliary scintigraphy, gallbladder emptying, liver cirrhosis, technetium-99m-N- (2, 6-diethylphenylcarbamoylmethyl) iminodiacetic acid

JOURNAL FREE ACCESS

1989 Volume 38 Issue 6 Pages 269-274

DOI https://doi.org/10.3769/radioisotopes.38.6_269

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Abstract

Gallbladder emptying after intramuscular injection of cerulein was investigated by ^99mTc-EHIDA hepatobiliary scintigraphy in 23 patients with biliary disease, 55 patients with chronic liver disease, and 21 normal controls.
The mean gallbladder ejection fraction in patients with gallstones and liver cirrhosis was significantly reduced compared with normal controls. (gallstones: 56.3±21.3%, LC with gallstones: 50.8±29.6%, LC without gallstones: 55.9±26.7%, vs, normal controls: 74.4±12.9%, p<0.01) .
The mechanism for sluggish gallbladder emptying in liver cirrhosis is unknown, however impaired emptying with bile stasis provides a potential pathophysiologic basis for the high frequency of pigment stones.

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