RADIOISOTOPES
Online ISSN : 1884-4111
Print ISSN : 0033-8303
ISSN-L : 0033-8303
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Review Article
  • Yasuhito Sasaki
    2025 Volume 74 Issue 1 Pages 63-71
    Published: March 15, 2025
    Released on J-STAGE: January 08, 2025
    JOURNAL OPEN ACCESS

    Practice of nuclear medicine (NM) in Japan started in 1950 when radioisotopes (RIs) were imported from the U.S.A. and Japan Radioisotope Association (JRIA) launched with the purpose for bulk buying and distribution of RIs to each user. The author has experienced the nuclear medicine practices since its dawn to present. The purpose of this historical review is to follow tracks of nuclear cardiology in Japan as seen by the author. The nation-wide survey of nuclear medicine practice in Japan which was conducted by a subcommittee of JRIA tells us numbers of examinations, instruments and radiopharmaceuticals used for cardiac imaging and their temporal changes. The author describes his experiences with cardiac imaging in NM and its chronological changes in accordance with developments of imaging devices and radiopharmaceuticals used. The author believes the new developments in instrumentations and radiopharmaceuticals together with multi-disciplinary cooperation will facilitate nuclear cardiology and contribute to welfare of patients.

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Mini Review
  • Kiyonori Yamaoka, Takahiro Kataoka
    2025 Volume 74 Issue 1 Pages 87-89
    Published: March 15, 2025
    Released on J-STAGE: February 06, 2025
    JOURNAL OPEN ACCESS

    The scientific evidence for the medical application of thoron, an isotope of radon, remains to be insufficient internationally. In addition, the ICRP reported that thoron progeny nuclides show higher radiobiological effects than radon progeny nuclides. For this reason, we outlined some of the research results that we have so far reported the biological effects of thoron and comparison with those of radon. As a result, we were able to suggest that, like radon ingestion, thoron ingestion enhances antioxidant function through physiological stimulation caused by the generation of trace amounts of active oxygen, thereby alleviating the symptoms of oxidative stress-related diseases. In addition, we found that thoron appears in a range with a lower optimal inhalation concentration than radon due to the difference in radioactivity characteristics, which is consistent with the ICRP report.

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