Antimelanoma Differentiation-associated Gene 5 (MDA5) Antibody-positive Interstitial Pneumonia with Bronchial Lesions

Abstract

We describe a patient with antimelanoma differentiation-associated gene 5 (MDA5) antibody-positive interstitial pneumonia without cutaneous features. The lung specimen obtained from transbronchial lung biopsy revealed interstitial pneumonia. In addition, scattered white lesions were observed on the central bronchi. The pathology of the bronchial lesion was confirmed as squamous metaplasia. We successfully treated the patient with steroids and tacrolimus. The bronchial lesions were improved in parallel with the interstitial pneumonia. These bronchial lesions could be a manifestation of anti-MDA5 antibody-positive interstitial pneumonia.