Abstract
An unusual occurrence of bilateral breast cancer in a 60-year-old woman with von Recklinghausen's disease is reported. Although there were metastases in the bone, the patient underwent bilateral musclepreserving mastectomy (Br+Ax). In the TNM classification, the left breast cancer was T2aN1M1 and the right one was T2aN0M1. Histologically, both were papillotubular carcinomas. The left breast cancer was negative and the right one was positive for both estrogen and progestron receptors.
There are two types of malignant neoplasms associated with von Recklinghausen's disease. One is sarcomatous transformation of neurofibroma and the other type is of association with other malignant neoplasms. Seventy four cases of non-neurogenic malignancies associated with von Recklinghausen's disease in the Japanese literature are reviewed and the problems concerning bilateral breast cancer are also discussed.
