1988 Volume 49 Issue 5 Pages 796-801
In patients with unresectable hepatic tumor or primary hepatic cancer with liver cirrhosis submitted to tumor cryosurgery, the more fluid is removed by from intraperitoneal drainage the better is the prognosis for prolongation of the postoperative survival period. In the present investigation, the effect of the patient's fluid on phytohemagglutinin (PHA)-, and concanavalin A (Con A)-induced lymphoblastogenesis was determined. When fluid obtained at 3, 24, 72 hours and 1, 3 week (s) postoperatively was added to the medium, PHA-induced blastogenesis of the patients peripheral blood lymphocytes (PBL) was reduced, while that of PBL of normal volunteers was increased. When fluid obtained at 24 hours and 3 weeks postoperatively was added to the medium, Con A-induced blastogenesis of the patient's PBL, as well as that of normal volunteers, was increased.
These results show that the patient's fluid might reduced effect host cell-mediated immunity, and support the idea that adequate drainage of fluid is useful for preventing high-zone tolerance which may be induced by the absorption of cryonecrotized tumor antigen during the early postoperative period.
