1989 Volume 50 Issue 12 Pages 2507-2512
Ceftizozime (CZX) was compared with piperacillin (PIPC) for prophylactic effect in patients undergoing elective gastric surgery, One hundred patients were randomized to receive either CZX or PIPC, which was given as an initial dose of 2g by i.v. drip infusion in the operating room before surgery, followed by 1g i.v. drip 8 hourly for 4 days. Forty-nine cass including 4 withdrawn ones were given CZX and 51 PIPC. The groups were comparable in age, sex, type of intervention and diagnosis. Eight patients in CZX group (17.8%) (2 with wound sepsis, 5 with intra-abdominal infection and 1 with other), and 19 in PIPC group (37.3%) (1 with wound sepsis, 12 with intraabdominal infection and 6 with others) developed postoperative infections, in which a significant difference was noted (p<0.05). There were no side effects such as diarrhea in either group. In the early postoperative period, abnormal liver function was noted in 25 patients (13 in CZX and 12 in PIPC group). Postoperative renal dysfunction was observed in 1 patient in PIPC group. No significant difference between the both groups was observed in the occurrence of adverse reactions or abnormal laboratory features. This study suggests that, compared to PIPC, CZX is a better prophylactic antibiotic for patients undergoing elective gastric surery.
