RELATIONSHIP BETWEEN NUCLEAR DNA CONTENT AND MALIGNANCY OF COLORECTAL CANCER

Abstract

The nuclear DNA content of parraffin-embedded materials was measured by cytofluorometry in 82 colorectal cancers, and the relationship between those histogram and clinicopathologic findings was investigated. The DNA histogram pattern was not related to clinicopathologic findings and stage. However, in absolutely and curatively resected cases, five year-survival rate of cases with diploid pattern was significantly higher than those with non-diploid pattern. Those observations suggest that the nuclear DNA histogram in colorectal cancer may be an important prognostic factor, being independent of pathologic stage.