A case of acute pulmonary embolism after skin graft is reported. A 69-year-old female underwent skin graft for a burn on the right knee on May 11, 1989. On the sixth operative day, she suddenly developed anterior chest pain and dyspnea after micturition, and followed by shock condition. Pulmonary embolism was strongly suspected and the anticoagulant and thrombolytic therapy was immediately initiated. Prostaglandin E1 was added by drip infusion. Pumonary scintigram 7 days after the onset showed blood flow defects in the middle and lower lobe of the right lung. A diagnosis of acute pulmonary embolism was made. The patient made favorable progress after medical treatment and pulmonary scintigram 37 days after the onset revealed a marked remission. She was discharged on June 30. In conclusion, acute pulmonary embolism should be cosidered as one of the critical complications after operation and early diagnosis followed by immediate initiation of the treatment are important.