Abstract
Using 50 patients undergoing pancreato-spleno-total gastrectomy (PST) for the treatment of gastric carcinoma or malignant lymphoma of the stomach, changes in postoperative glycometabolism were studied with the guidance of intravenous glucose tolerance test (IVGTT) and glycosylated hemoglobin (HbA1, HbA1c).
As a result, reduction of glucose tolerance was noted on these cases, probably due to reduced secretion of insulin occurred after pancreatectomy including the body and tail. It is suggested that pancreatectomy at more than 50% including the body and tail performed simultaneously with total gastrectomy can cause diabetes mellitus. Such reduction in glucose tolerance in patients undergoing PST appeared to be progressive and irreversible.
These results recommend to follow up the post-PST patients with the strict and prolonged management, making effective use of IVGTT and glycosylated hemoglobin.
