Abstract
A very rare case of multiple advanced carcinoma of the gallbladder in the different histological types was experienced.
The patient was a 69-year-old man. Ultrasonography revealed a 3×3×cm elevated lesion and wall thickness. The lesion was diagnosed as carcinoma of the gallbladder. Intravenous cholangiography showed no visualization of the gallbladder. Possible coexistence of some lesion in the neck was suspected, but no lesion was found by US and CT. Simple cholecystectomy was made.
Gross examination of the excised specimen showed carcinomas of 4×4×4 cm in the fundus, and 1×1×cm in the neck. No abnormal findings were not found between two lesions. Microscopic examination revealed adenosquamous cell carcinoma in the fundes and adenocarcinoma in the neck. Both lesions were advanced carcinoma in the same level (ss).
There was no intramucosal invasion nor vessel invasion between two lesions. Preoperative examination, operative findings, and examination of excised specimen, there were no direct invasion, lymphnode metastasis, nor distant metastasis. So we could not find no biological differentiation between two lesions.
