Abstract
To investigate the role of vagus nerve on gut hormone secretion, vagal stimulation evoked by insulin hypoglycemia was loaded for the patients with peptic ulcer before and after vagotomy, and the changes in blood levels of gastrin and secretion were observed. Simultaneously gastric juice was collected and gastric acid output was measured.
Before operation, serum gastrin level increased with insulin hypoglycemia. After selective proximal vagotomy (SPV), serum gastrin level also increased with vagal stimulation. On the other hand after total truncal vagotomy (TV), serum gastrin level did not change with insulin hypoglycemia. Plasma secretion level did not change with insulin hypoglycemia both before and after vagogomy. Gastric acid output decreased after SPV and TV. These findings indicate that SPV is not inferior to TV in decreasing gastric acid output, but also it is more excellent in terms of postoperative gut hormone dynamics and preservation of the peptic function.
