CLINICAL STUDY ON GASTRECTOMY COMBINED HEPATECTOMY FOR GASTRIC CANCER WITH SYNCHRONOUS LIVER METASTASES-ESPECIALLY ON THE RELATIONSHIP BETWEEN THE PROGNOSIS AND NUCLEAR DNA CONTENTS, IMMUNOHISTOCHEMICAL STAINING OF CEA IN BOTH FOCI OF PRIMARY AND METASTATIC LESION

Abstract

In 10 relative noncurative gastric cancer cases, undergoing gasterectomy combined hepatectomy, the relationships between the prognosis and biological characters (including nuclear DNA contents and the immunohistochemical staining of tumor markers such as CEA and AFP) in both primary and liver metastatic foci were investigated.
Of the 10 cases 3 survive for more than 3 years, while, 5 out of the remaining 7 cases died of recurrence of cancer in the remnant liver. In 3 out of 5 long survival cases, the nuclear DNA contents showed low ploidy patterns in both foci. On the other hand, in 4 out of 5 short survival cases, it showed high ploidy patterns in both foci. The remaining one of the 4 had the multiplicity in nuclear DNA patterns, namely, it was low ploid in the primary but high ploid in the metastatic foci. In immunohistochemical CEA staining, one long survival case showed positive CEA in primary and negative one in the liver. It is suggested that the postoperative prognosis of the gastric cancer with liver metastasis might be related with the multiplicity in the biological characters between the primary and metastatic foci.